General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-TSHZ3 (791-890) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | TSHZ3 |
| Gene ID: | 57616 |
| Uniprot ID: | TSH3_HUMAN |
| Immunogen Region: | 791-890 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 791-890 of human TSHZ3 (NP_065907.2). |
| Immunogen Sequence: | DLTKGKSDKGCSLGSVLLSP TSTAPATSSSTVTTAKTSAV VSFMSNSPLRENALSDISDM LKNLTESHTSKSSTPSSISE KSDIDGATLEEAEESTPAQK |
Description
| Tissue Specificity | Expressed in brain.strongly reduced in post-mortem elderly subjects with Alzheimer disease. Expressed in the fetal neocortex. |
| Function | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation. |
| Protein Name | Teashirt Homolog 3Zinc Finger Protein 537 |
| Cellular Localisation | NucleusCell ProjectionGrowth ConeColocalizes With Apbb1 In Axonal Growth ConeColocalizes With Apbb1 In The Nucleus |
| Alternative Antibody Names | Anti-Teashirt Homolog 3 antibodyAnti-Zinc Finger Protein 537 antibodyAnti-TSHZ3 antibodyAnti-KIAA1474 antibodyAnti-TSH3 antibodyAnti-ZNF537 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance