Anti-TRABID/ZRANB1 antibody (C-Term)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-1-3µg/ml ELISA-antibody detection limit dilution 1:4000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ZRANB1
Gene ID:	54764
Uniprot ID:	ZRAN1_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_060050.2
Immunogen Sequence:	KWLDRYRQIRPCTS

Function	Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
Protein Name	Ubiquitin Thioesterase Zranb1 Traf-Binding Domain-Containing Protein Htrabid Zinc Finger Ran-Binding Domain-Containing Protein 1
Database Links	Reactome: R-HSA-195253 Reactome: R-HSA-5689896
Cellular Localisation	Cytoplasm Nucleus Enriched In Punctate Localization In The Cytoplasm
Alternative Antibody Names	Anti-Ubiquitin Thioesterase Zranb1 antibody Anti-Traf-Binding Domain-Containing Protein antibody Anti-Htrabid antibody Anti-Zinc Finger Ran-Binding Domain-Containing Protein 1 antibody Anti-ZRANB1 antibody Anti-TRABID antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance