Anti-SDCBP antibody

Clonality:	Monoclonal
Conjugation:	Unconjugated
Formulation:	Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol.
Purification:	Affinity purification
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SDCBP
Gene ID:	6386
Uniprot ID:	SDCB1_HUMAN
Specificity:	Syntenin-1 Monoclonal Antibody detects endogenous levels of Syntenin-1 protein.
Immunogen:	Purified recombinant human Syntenin-1 protein fragments expressed in E.coli.

Post Translational Modifications	Phosphorylated on tyrosine residues.
Function	Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Protein Name	Syntenin-1 Melanoma Differentiation-Associated Protein 9 Mda-9 Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18 Tacip18 Scaffold Protein Pbp1 Syndecan-Binding Protein 1
Database Links	Reactome: R-HSA-3928664 Reactome: R-HSA-447043 Reactome: R-HSA-5213460 Reactome: R-HSA-5675482 Reactome: R-HSA-6798695
Cellular Localisation	Cell Junction Focal Adhesion Adherens Junction Cell Membrane Peripheral Membrane Protein Endoplasmic Reticulum Membrane Nucleus Melanosome Cytoplasm Cytosol Cytoskeleton Secreted Extracellular Exosome Membrane Raft Mainly Membrane-Associated Localized To Adherens Junctions Focal Adhesions And Endoplasmic Reticulum Colocalized With Actin Stress Fibers Also Found In The Nucleus Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv Associated To The Plasma Membrane In The Presence Of Fzd7 And Phosphatidylinositol 4 5-Bisphosphate (Pip2)
Alternative Antibody Names	Anti-Syntenin-1 antibody Anti-Melanoma Differentiation-Associated Protein 9 antibody Anti-Mda-9 antibody Anti-Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18 antibody Anti-Tacip18 antibody Anti-Scaffold Protein Pbp1 antibody Anti-Syndecan-Binding Protein 1 antibody Anti-SDCBP antibody Anti-MDA9 antibody Anti-SYCL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance