General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-RTFDC1 (1-306) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | RTF2 |
| Gene ID: | 51507 |
| Uniprot ID: | RTF2_HUMAN |
| Immunogen Region: | 1-306 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human RTFDC1 (NP_057491.2). |
| Immunogen Sequence: | MGCDGGTIPKRHELVKGPKK VEKVDKDAELVAQWNYCTLS QEILRRPIVACELGRLYNKD AVIEFLLDKSAEKALGKAAS HIKSIKNVTELKLSDNPAWE GDKGNTKGDKHDDLQRARFI CPVVGLEMNGRHRFCFLRCC GCVFSERALKEIKAEVCHTC GAAFQEDDVIMLNGTKEDVD VLKTRMEERRLRAKLEKKTK KPKAAESVSKPDVSEEAPGP SKVKTGKPEEASLDSREKK |
Description
| Post Translational Modifications | Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability. |
| Function | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA. |
| Protein Name | Replication Termination Factor 2Rtf2Replication Termination Factor 2 Domain-Containing Protein 1 |
| Cellular Localisation | ChromosomeLocalizes At The Replication Fork |
| Alternative Antibody Names | Anti-Replication Termination Factor 2 antibodyAnti-Rtf2 antibodyAnti-Replication Termination Factor 2 Domain-Containing Protein 1 antibodyAnti-RTF2 antibodyAnti-C20orf43 antibodyAnti-RTFDC1 antibodyAnti-AD-007 antibodyAnti-CDA05 antibodyAnti-HSPC164 antibodyAnti-HSPC169 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance