General Info
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-MMP12 (371-470) is suitable for use in Western Blot research applications. |
Clonality: | Monoclonal |
Clone ID: | S8MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | MMP12 |
Gene ID: | 4321 |
Uniprot ID: | MMP12_HUMAN |
Immunogen Region: | 371-470 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 371-470 of human MMP12 (P39900). |
Immunogen Sequence: | FGFPNFVKKIDAAVFNPRFY RTYFFVDNQYWRYDERRQMM DPGYPKLITKNFQGIGPKID AVFYSKNKYYYFFQGSNQFE YDFLLQRITKTLKSNSWFGC |
Description
Tissue Specificity | Found in alveolar macrophages but not in peripheral blood monocytes. |
Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
Protein Name | Macrophage MetalloelastaseMmeMacrophage ElastaseMeHmeMatrix Metalloproteinase-12Mmp-12 |
Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
Alternative Antibody Names | Anti-Macrophage Metalloelastase antibodyAnti-Mme antibodyAnti-Macrophage Elastase antibodyAnti-Me antibodyAnti-Hme antibodyAnti-Matrix Metalloproteinase-12 antibodyAnti-Mmp-12 antibodyAnti-MMP12 antibodyAnti-HME antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance