Anti-MEK5 Antibody
Katalog-Nummer OAED00082
Size : 100ug
Marke : Aviva Systems Biology
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Telefonnummer : +1 850 650 7790
Anti-MEK5 Antibody (OAED00082)
| Datasheets/Manuals | Printable datasheet for Anti-MEK5 Antibody (OAED00082) |
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| Predicted Species Reactivity | Human, Mouse, Rat, Dog, Monkey, Rabbit, Sheep, Xenopus |
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| Clonality | Polyclonal |
| Host | Rabbit |
| Application | IHC, WB |
| Reconstitution and Storage | Long Term Storage : -20C |
| Immunogen | Synthetic peptide corresponding to a portion of human MEK5. The sequence is completely conserved in rat. |
| Specificity | Recognizes human, mouse, rat, dog, monkey, rabbit, sheep and Xenopus MEK5. Detects a band of ~42kDa by Western blot. |
| Formulation | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide. |
| Purity | Peptide affinity purified. |
| Application Info | Immunohistochemistry Western Blot (1:1000, ECL) Optimal conditions must be determined individually for each application. |
| Reference | MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion: H.Y. Leung, et al. ; Oncogene 22, 1381 (2003), Application(s): IHC using human samples, Abstract; MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway: J.D. Lee, et al. ; J. Biol. Chem. 274, 36035 (1999), Application(s): WB using mouse samples, Abstract; |
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| Gene Symbol | MAP2K5 |
| Alias Symbols | MEK5, MAPKK5, PRKMK5, HsT17454 |
| NCBI Gene Id | 5607 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 5 |
| Description of Target | MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. |
| Uniprot ID | Q13163 |
