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Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

Anti-Cav1.2 Ca2+ Channel Antibody FL594 Conjugate

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Katalog-Nummer 75-257-FL594

Size : 200uL

Contact local distributor :

Telefonnummer : +1 850 650 7790

Marke : Antibodies Incorporated

Contact local distributor :

Telefonnummer : +1 850 650 7790

Our Anti-Cav1.2 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N263/31. It detects human, mouse, and rat Cav1.2 Ca2+ channel, and is purified by Protein A chromatography. It is great for use in ICC.

Species Reactivity

Guinea Pig, Human, Mouse, Rabbit, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

550

650

Data Sheet

SKU: 75-257-FL594

Product Details

Target

Cav1.2 Ca2+ channel

Target Description

Voltage-dependent L-type calcium channel subunit alpha-1C or Cav1.2 calcium channel (other names include as CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1 ) is a calcium channel encoded by the gene CACNA1C. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.2 is expressed in many tissues including smooth muscle, liver, kidney brain and heart. In brain, it can be detected in the hippocampus and brain cortex in the post-synaptic density and in neuronal cell bodies. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Mutations in the Cav1.2 gene have been associated with Timothy syndrome, Brugada syndrome 3 and Long QT syndrome 8.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N263/31

Isotype

IgG2b

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1

Molecular Weight

240 kDa

Antigen

Fusion protein amino acids 808-874 (cytoplasmic loop between repeat II and III) of rat Cav1.2 (accession number Q5S007) produced recombinantly in E. Coli

Species Reactivity

Guinea Pig, Human, Mouse, Rabbit, Rat

Antibody Registry ID

AB_2939934

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

Does not cross-react with Cav1.3

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)

UniProt Details

UniProt (Human): Q13936
UniProt (Immunogen Species): P22002

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