General Info
| Host: | Mouse |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat/Cow/Dog/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Integrin alpha-6 (N-Term) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Conjugation: | Unconjugated |
| Formulation: | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Purification: | Affinity purification |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-1:2000IF 1:100-1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ITGA6 |
| Gene ID: | 3655 |
| Uniprot ID: | ITA6_HUMAN |
| Immunogen Region: | N-Term |
| Specificity: | Integrin Alpha 6 Monoclonal Antibody detects endogenous levels of Integrin Alpha 6 protein. |
| Immunogen: | Purified recombinant human Integrin Alpha 6 (N-terminus) protein fragments expressed in E.coli. |
Description
| Post Translational Modifications | Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p). Production of alpha6p enhances prostate cancer cell invasion and migration. Palmitoylation by DHHC3 enhances stability and cell surface expression. |
| Function | Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. |
| Protein Name | Integrin Alpha-6Cd49 Antigen-Like Family Member FVla-6Cd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6Alpha6p |
| Database Links | Reactome: R-HSA-2022090Reactome: R-HSA-210991Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-3000170Reactome: R-HSA-446107 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-Anchor |
| Alternative Antibody Names | Anti-Integrin Alpha-6 antibodyAnti-Cd49 Antigen-Like Family Member F antibodyAnti-Vla-6 antibodyAnti-Cd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6 antibodyAnti-Alpha6p antibodyAnti-ITGA6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance