This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 28°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit AntiHuman CCR5 recognizes an epitope near the Nterminus of Human CCR5. This polyclonal antibody was purified using affinity chromatography.

Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G proteincoupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CCCKR5) is a principal coreceptor for macrophage and dualtropic HIV1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV1, HIV2, and SIV. The bchemokines RANTES, MIP1α and MIP1β are the ligands for CCR5 and prevent infection by Mtropic HIV1. CXC5 associates with the surface CD4gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The aminoterminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

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