Anti-Cathepsin K antibody (Internal)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-1-3µg/ml ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CTSK
Gene ID:	1513
Uniprot ID:	CATK_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_000387.1
Immunogen Sequence:	KTHRKQYNNKVDE

Function	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
Protein Name	Cathepsin K Cathepsin O Cathepsin O2 Cathepsin X
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-1679131 Reactome: R-HSA-2132295 Reactome: R-HSA-8939242
Cellular Localisation	Lysosome Secreted Apical Cell Membrane Peripheral Membrane Protein Extracellular Side Localizes To The Lumen Of Thyroid Follicles And To The Apical Membrane Of Thyroid Epithelial Cells
Alternative Antibody Names	Anti-Cathepsin K antibody Anti-Cathepsin O antibody Anti-Cathepsin O2 antibody Anti-Cathepsin X antibody Anti-CTSK antibody Anti-CTSO antibody Anti-CTSO2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance