General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ADCY10 (1-290) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ADCY10 |
| Gene ID: | 55811 |
| Uniprot ID: | ADCYA_HUMAN |
| Immunogen Region: | 1-290 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human ADCY10 (NP_060887.2). |
| Immunogen Sequence: | MNTPKEEFQDWPIVRIAAHL PDLIVYGHFSPERPFMDYFD GVLMFVDISGFTAMTEKFSS AMYMDRGAEQLVEILNYHIS AIVEKVLIFGGDILKFAGDA LLALWRVERKQLKNIITVVI KCSLEIHGLFETQEWEEGLD IRVKIGLAAGHISMLVFGDE THSHFLVIGQAVDDVRLAQN MAQMNDVILSPNCWQLCDRS MIEIESVPDQRAVKVNFLKP PPNFNFDEFFTKCTTFMHY |
Description
| Tissue Specificity | Detected in airway epithelial cells and testis (at protein level). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. |
| Post Translational Modifications | Cleavage may occur to generate the active 48 kDa form. |
| Function | Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. |
| Protein Name | Adenylate Cyclase Type 10Ah-Related ProteinAdenylate Cyclase HomologGerm Cell Soluble Adenylyl CyclaseHsacSacTesticular Soluble Adenylyl Cyclase |
| Database Links | Reactome: R-HSA-5610787 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonPerinuclear RegionNucleusCell ProjectionCiliumMitochondrionDistributed To Subcellular Compartments Containing Camp TargetsFound As A Plasma Membrane-Associated ProteinProtein Concentrated In The Perinuclear Region And Protein Colocalized With Actin Or Tubulin |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 10 antibodyAnti-Ah-Related Protein antibodyAnti-Adenylate Cyclase Homolog antibodyAnti-Germ Cell Soluble Adenylyl Cyclase antibodyAnti-Hsac antibodyAnti-Sac antibodyAnti-Testicular Soluble Adenylyl Cyclase antibodyAnti-ADCY10 antibodyAnti-SAC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance