Amantadine [768-94-5]
Katalog-Nummer HY-B0402-500mg
Size : 500mg
Marke : MedChemExpress
Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Amantadine Chemische Struktur
CAS. Nr. : 768-94-5
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Other Forms of Amantadine:
- Amantadine hydrochloride In-stock
- Amantadine-d15 In-stock
- Amantadine-d6 In-stock
- Amantadine sulfate Angebot einholen
Beschreibung |
Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6]. |
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In Vitro |
Amantadine (0-500 µM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 µM[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[4]
Cell Proliferation Assay[6]
Cell Cycle Analysis[6]
Apoptosis Analysis[6]
Western Blot Analysis[6]
RT-PCR[6]
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In Vivo |
Amantadine (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Klinische Studie |
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Molekulargewicht |
151.25 |
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Formel |
C10H17N |
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CAS. Nr. |
768-94-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
NC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3 |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 10 mg/mL (66.12 mM; ultrasonic and adjust pH to 2 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 6.6116 mL | 33.0579 mL | 66.1157 mL | 165.2893 mL |
5 mM | 1.3223 mL | 6.6116 mL | 13.2231 mL | 33.0579 mL | |
10 mM | 0.6612 mL | 3.3058 mL | 6.6116 mL | 16.5289 mL | |
15 mM | 0.4408 mL | 2.2039 mL | 4.4077 mL | 11.0193 mL | |
20 mM | 0.3306 mL | 1.6529 mL | 3.3058 mL | 8.2645 mL | |
25 mM | 0.2645 mL | 1.3223 mL | 2.6446 mL | 6.6116 mL | |
30 mM | 0.2204 mL | 1.1019 mL | 2.2039 mL | 5.5096 mL | |
40 mM | 0.1653 mL | 0.8264 mL | 1.6529 mL | 4.1322 mL | |
50 mM | 0.1322 mL | 0.6612 mL | 1.3223 mL | 3.3058 mL | |
60 mM | 0.1102 mL | 0.5510 mL | 1.1019 mL | 2.7548 mL |
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Amantadine768-94-51-Adamantanamine 1-AminoadamantaneInhibitorinhibitorinhibit