ALB Antibody - Biotin Conjugated
Katalog-Nummer OACA00145
Size : 100ug
Marke : Aviva Systems Biology
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Telefonnummer : +1 850 650 7790
Phospho-MDM2 (S166) Recombinant Antibody [14F8] (OACA12877)
| Datasheets/Manuals | Printable datasheet for MDM2 Recombinant Antibody [14F8] (OACA12877) |
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| Predicted Species Reactivity | Human |
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| Product Format | Liquid |
| Clonality | Recombinant Monoclonal |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay, Flow cytometry, Immunofluorescence, Immunohistochemistry |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | A synthesized peptide derived from Human MDM2 |
| Purification | Affinity Purified |
| Gene Symbol | MDM2 |
|---|---|
| Gene Full Name | MDM2 proto-oncogene |
| Alias Symbols | ACTFS;Double minute 2 protein;double minute 2, human homolog of; p53-binding protein;E3 ubiquitin-protein ligase Mdm2;hdm2;HDMX;LSKB;MDM2 oncogene, E3 ubiquitin protein ligase;MDM2 proto-oncogene, E3 ubiquitin protein ligase;Mdm2, p53 E3 ubiquitin protein ligase homolog;Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;oncoprotein Mdm2;p53-binding protein Mdm2;RING-type E3 ubiquitin transferase Mdm2. |
| NCBI Gene Id | 4193 |
| Protein Name | E3 ubiquitin-protein ligase Mdm2 |
| Description of Target | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). |
| Uniprot ID | Q00987 |