Western Blot (Recombinant protein)

ELISA

Immunofluorescence

Immunofluorescence of monoclonal antibody to AKT1 on HeLa cell . [antibody concentration 10 ug/ml]

Entrez GeneID

207

GeneBank Accession#

BC000479

Protein Accession#

AAH00479.1

Gene Name

AKT1

Gene Alias

AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA

Gene Description

v-akt murine thymoma viral oncogene homolog 1

Omim ID

164730 181500

Gene Ontology

Hyperlink

Gene Summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq

Other Designations

RAC-alpha serine/threonine-protein kinase|murine thymoma viral (v-akt) oncogene homolog-1|protein kinase B|rac protein kinase alpha