Ajmaline [4360-12-7]
Katalog-Nummer HY-B1167-50mg
Size : 50mg
Marke : MedChemExpress
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Ajmaline Chemische Struktur
CAS. Nr. : 4360-12-7
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Beschreibung |
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia[1][2]. |
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In Vitro |
Electrophysiological experiments are performed with human embryonic kidney (HEK) cells (whole-cell patch clamp) and Xenopus oocytes (double-electrode voltage clamp) expressing wild-type and mutant HERG channels. Ajmaline blocks HERG currents with an IC50 of 1.0μM in HEK cells and 42.3μM in Xenopus oocytes[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Klinische Studie |
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Molekulargewicht |
326.43 |
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Formel |
C20H26N2O2 |
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CAS. Nr. |
4360-12-7 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
CN1C2=CC=CC=C2[C@@]34[C@]1(03)[C@@](C[C@H]5[C@H](CC)[C@H]6O)(03)[N@]6[C@](03)([C@H]5[C@H]4O)C3 |
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Structure Classification |
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Initial Source |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : ≥ 100 mg/mL (306.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.82% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.0634 mL | 15.3172 mL | 30.6344 mL | 76.5861 mL |
5 mM | 0.6127 mL | 3.0634 mL | 6.1269 mL | 15.3172 mL | |
10 mM | 0.3063 mL | 1.5317 mL | 3.0634 mL | 7.6586 mL | |
15 mM | 0.2042 mL | 1.0211 mL | 2.0423 mL | 5.1057 mL | |
20 mM | 0.1532 mL | 0.7659 mL | 1.5317 mL | 3.8293 mL | |
25 mM | 0.1225 mL | 0.6127 mL | 1.2254 mL | 3.0634 mL | |
30 mM | 0.1021 mL | 0.5106 mL | 1.0211 mL | 2.5529 mL | |
40 mM | 0.0766 mL | 0.3829 mL | 0.7659 mL | 1.9147 mL | |
50 mM | 0.0613 mL | 0.3063 mL | 0.6127 mL | 1.5317 mL | |
60 mM | 0.0511 mL | 0.2553 mL | 0.5106 mL | 1.2764 mL | |
80 mM | 0.0383 mL | 0.1915 mL | 0.3829 mL | 0.9573 mL | |
100 mM | 0.0306 mL | 0.1532 mL | 0.3063 mL | 0.7659 mL |
Ajmaline Related Classifications
- Membrane Transporter/Ion Channel
- Sodium Channel