Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AdipoRon [924416-43-3]
Katalog-Nummer T2257-10mg
Size : 10mg
Marke : TargetMol
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AdipoRon
Catalog No. T2257 CAS 924416-43-3
Synonyms: SC-396658
AdipoRon (SC-396658) is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).
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AdipoRon, CAS 924416-43-3
| Description | AdipoRon (SC-396658) is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM). |
| Targets&IC50 | AdipoR2:3.1 μM(Kd), AdipoR1:1.8 μM(Kd) |
| In vitro | In wild-type mice, AdipoRon administered orally (50 mg/kg) activates the AdipoR2–PPAR-α pathway in the liver or the AdipoR1–AMPK–PGC-1α pathway in skeletal muscle, thereby improving insulin resistance, lipid abnormalities, and glucose tolerance. In the skeletal muscle and liver of WT mice, AdipoRon (50 mg/kg, intravenously) significantly induces phosphorylation of AMPK via AdipoR1/2. Furthermore, AdipoRon ameliorates diabetic symptoms in the genetic obesity murine model db/db mice and extends the shortened lifespan of db/db mice on a high-fat diet. |
| In vivo | AdipoRon, through its interaction with AdipoR1/2 in C2C12 myotubes, enhances the activation of AMPK and promotes the expression of PGC-1α as well as mitochondrial biogenesis. |
| Cell Research | The effects of AdipoRon on the proliferation of parenchymal and non-parenchymal hepatocytes are evaluated in vitro via L02 and RAW264.7, by MTT assay as described with slight modification: 100 μL cells suspension (6×104/mL) are seeded in a 96-well plate and incubated for 18 h. Fresh media with AdipoRon are added at specified concentrations, and the incubations continue for a further 24 h. Then cells are incubated for 4 h with 0.5 mg/mL of MTT, and analyzed in a microplate reader at 490 nm. Each group is performed in six replications. The mean absorbance values corrected for a blank (medium only) are calculated as percentages of survival. |
| Synonyms | SC-396658 |
| Molecular Weight | 428.52 |
| Formula | C27H28N2O3 |
| CAS No. | 924416-43-3 |
Storage
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 47 mg/mL (109.7 mM)
DMSO: 80 mg/mL (186.7 mM)
References and Literature
Citations
1. He Z, Liu S, Li Z, et al. Coaxial TP/APR electrospun nanofibers for programmed controlling inflammation and promoting bone regeneration in periodontitis-related alveolar bone defect models. Materials Today Bio. 2022: 100438. 2. Yang J, Wang Z X, Fang L, et al. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221. Journal of Ethnopharmacology. 2023, 300: 115688.