Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Ketocholesterol [566-28-9]
Katalog-Nummer TN6715-1mL
Size : 1mL
Marke : TargetMol
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7-Ketocholesterol
Catalog No. TN6715 CAS 566-28-9
7-Ketocholesterol is a metabolite of Cholesterol
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7-Ketocholesterol, CAS 566-28-9
| Description | 7-Ketocholesterol is a metabolite of Cholesterol |
| In vivo | 7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation.?7KC induces a dose-dependent loss of cell viability and an increase in apoptosis and necrosis in the endothelial cells.?A relocalization of the tight junction proteins, zonula occludens-1 (ZO-1) and claudin-5, towards the nucleus of the cells was also observed.?These effects were significantly attenuated by ET. In addition, 7KC induces marked increases in the mRNA expression of pro-inflammatory cytokines, IL-1β IL-6, IL-8, TNF-α and cyclooxygenase-2 (COX2), as well as COX2 enzymatic activity, and these were significantly reduced by ET. |
| Molecular Weight | 400.65 |
| Formula | C27H44O2 |
| CAS No. | 566-28-9 |
Storage
Solubility Information
DMSO: < 4.01mg (10 mM)
References and Literature
1. Anderson A , Campo A , Fulton E , et al. 7-Ketocholesterol in disease and aging[J]. Redox Biology, 29. 2. SS Koh, Ooi C Y , Lui M Y , et al. Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury[J]. NeuroMolecular Medicine, 2020:1-15.