N-Biotinylcaproylaminoethyl Methanethiosulfonate (MTSEA-BIOTINCAP)

Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease.

122-124°C

DMSO, methanol

Proton (DMSO-d6) NMR Spectroscopic and Mass Spectrometric Analysis

SiO2; Dichloromethane: Methanol=4:1;. Visualized with AMCS; Single spot; Rf=0.55.

Moisture-sensitive. Some methanethiosulfonates are hygroscopic and all hydrolyze in water, over a period of time, particularly in the presence of nucleophiles. They should be stored in a desiccator at -20°C and warmed up to RT before opening the vial. For maximum results, solutions should be made up immediately prior to use even though solutions in distilled water appear to be stable for hours at 4°C.

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