Cholesterol [57-88-5]
Katalog-Nummer HY-N0322-500mg
Size : 500mg
Marke : MedChemExpress
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
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Cholesterol Chemische Struktur
CAS. Nr. : 57-88-5
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Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist. | ||||||||||||||||
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In Vitro | GT1-7 hypothalamic cells subjected to Cholesterol depletion in vitro produced 20-31% reductions in cellular Cholesterol content. All Cholesterol-depleted neuron-derived cells, exhibit decreased phosphorylation/activation of IRS-1 and AKT following stimulation by insulin, insulin-like growth factor-1, or the neurotrophins (NGF and BDNF). Reduction in cellular Cholesterol also results in increased basal autophagy and impairment of induction of autophagy by glucose deprivation. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||||||||
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In Vivo | Cholesterol can be used in animal modeling to construct a rat model of hyperlipidemia. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||||||||
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386.65 | ||||||||||||||||
C27H46O | ||||||||||||||||
57-88-5 | ||||||||||||||||
Solid | ||||||||||||||||
White to off-white | ||||||||||||||||
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3(16)[C@]2(16)CC[C@@]4(C)[C@@]3(16)CC[C@]4(16)[C@@H](CCCC(C)C)C | ||||||||||||||||
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Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
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In Vitro: Ethanol : 20 mg/mL (51.73 mM; Need ultrasonic) DMSO : < 1 mg/mL (insoluble or slightly soluble) Preparing Stock Solutions
View the Complete Stock Solution Preparation Table * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo: Select the appropriate dissolution method based on your experimental animal and administration route. For the following dissolution methods, please ensure to first prepare a clear stock solution using an and then sequentially add co-solvents:
In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL | ||||||||||||||||
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[1]. Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525.
[2]. Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97.
[3]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14.
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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Ethanol | 1 mM | 2.5863 mL | 12.9316 mL | 25.8632 mL | 64.6580 mL |
5 mM | 0.5173 mL | 2.5863 mL | 5.1726 mL | 12.9316 mL | |
10 mM | 0.2586 mL | 1.2932 mL | 2.5863 mL | 6.4658 mL | |
15 mM | 0.1724 mL | 0.8621 mL | 1.7242 mL | 4.3105 mL | |
20 mM | 0.1293 mL | 0.6466 mL | 1.2932 mL | 3.2329 mL | |
25 mM | 0.1035 mL | 0.5173 mL | 1.0345 mL | 2.5863 mL | |
30 mM | 0.0862 mL | 0.4311 mL | 0.8621 mL | 2.1553 mL | |
40 mM | 0.0647 mL | 0.3233 mL | 0.6466 mL | 1.6164 mL | |
50 mM | 0.0517 mL | 0.2586 mL | 0.5173 mL | 1.2932 mL |
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Cholesterol57-88-5LiposomeEstrogen Receptor/ERREndogenous MetaboliteBacterialDiabetesSREBP2insulinphosphorylationIRS-1AKTexocyticunesterifiedtransporterssignalingERRαInhibitorinhibitorinhibit
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