Order number: BN0873
Category: Other Enzyme Inhibitors/Substrates/Activators
Research area: Miscellaneous Enzyme
Description: Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM; human O-GlcNAcase). It decreases phosphorylation of tau (t) protein in PC-12 cells at pathologically relevant sites including Thr231 and Ser396. Treatment of hemizygous JNPL3 tau transgenic mice with Thiamet G increases tau O-GlcNAc, inhibits formation of tau aggregates and decreases neuronal cell loss. O-GlcNAcase may be a potential therapeutic target that could hinder progression of Alzheimer's disease (AD).
CAS Number: 1009816-48-1
Price: 140,00 EUR