Initiation Factors

EIF-4E; PROTEIN SYNTHESIS INITIATION FACTOR 4E

GLO118 [1 mg, € 380,-]

Cap-binding protein involved in rate limiting step in protein synthesis. Undergoes phosphorylation at Ser²⁰⁹ in response to growth factors and other extracellular stimuli. Occurs as a complex with eIF-4BP’s and as part of the eIF-4F complex.

J Biol Chem 270: 14824

EIF-4E^S209A ; PHOSPHORYLATION SITE MUTANT

GLO119 [1 mg, € 380,-]

eIF-4E (GLO118, this page) undergoes phosphorylation at Ser²⁰⁹ in response to growth factors and other extracellular stimuli. Purified eIF-4E^S209A is used in studies of the functional significance of this phosphorylation.

1. J Biol Chem 270: 14824
2. J Biol Chem 270: 14597
3. J Biol Chem 271: 11831
4. J Biol Chem 270: 21684

EIF-4E^T210A ; PHOSPHORYLATION SITE MUTANT

GLO120 [1 mg, € 380,-]

In addition to Ser²⁰⁹, eIF-4E (GLO118, this page) undergoes phosphorylation at Thr²¹⁰. eIF-4E^T210A is used in studies of the functional significance of Thr210 phosphorylation.

J Biol Chem 270: 14824

EIF-4E^S209T210A ; PHOSPHORYLATION SITE MUTANT

GLO121 [1 mg, € 380,-]

Used to determine the functional significance of eIF-4E (GLO118, this page) phosphorylation at Ser²⁰⁹ and Thr²¹⁰.

J Biol Chem 270: 14824

EIF-4E^S53A ; STRUCTURAL MUTANT

GLO122 [1 mg, € 380,-]

Inactive form of eIF-4E (GLO118, this page) used as control in studies to determine the function of the native protein.

J Biol Chem 270: 14824

EIF-4E^S124A ; STRUCTURAL MUTANT

GLO123 [1 mg, € 380,-]

Used for functional studies of eIF-4E (GLO118, this page).

J Biol Chem 270: 14824